Diffusion Tensor Imaging in Mild Traumatic Brain Injuries – Acute State and Short-Term Recovery

Main Article Content

Armin Fuchs Angelica Hotiu, Ph.D Kelly J. Jantzen, Ph.D Fred Steinberg, M.D. J.A. Scott Kelso, Ph.D

Abstract

Mild traumatic brain injuries (MTBI), in most cases, cannot be detected using imaging modalities like CT or MRI. However, diffusion tensor imaging (DTI) reveals subtle changes in white matter integrity as a result of head trauma and plays an important role in refining diagnosis and management of MTBI. We use DTI to detect the microstructural changes in collegial football players induced by axonal injuries and to monitor their evolution during the recovery process. Three players suffered a MTBI during play or practice and underwent scanning within 24h with follow-ups after one and two weeks. Scalar diffusion indices were derived from diffusion tensors and analyzed using tract-based spatial statistics (TBSS) and voxel-wise t-tests to detect brain regions showing significant group differences between the injured subjects and controls. Both analyses revealed overlapping regions in the corticospinal tract with significant increase in fractional anisotropy and decreases in transverse and mean diffusivity within 24 hours. In voxel-wise t-tests strong indications for recovery were found spatially and temporally. For mean and transverse diffusivity, regions showing significant differences shrunk between the first and the follow-up scans. Although the sample size is small, these findings are remarkably consistent across all subjects and scans.

Article Details

How to Cite
FUCHS, Armin et al. Diffusion Tensor Imaging in Mild Traumatic Brain Injuries – Acute State and Short-Term Recovery. Medical Research Archives, [S.l.], v. 2, n. 1, aug. 2015. ISSN 2375-1924. Available at: <http://www.journals.ke-i.org/index.php/mra/article/view/320>. Date accessed: 20 nov. 2017.
Keywords
Diffusion tensor imaging (DTI), mild traumatic brain injuries (MTBI); fractional anisotropy (FA); diffusion indices
Section
Research Articles

References

Adams, J.H., Doyle, D., Ford, I., Gennarelli, T.A., Graham, D.I., McClellan, D.R., 1989. Diffuse axonal injury in head injury: definitions, diagnosis and grading. Histopathology 15:49-59.

Alves, W., Macciocchi, S., Barth, J.T., 1993. Postconcussive symptoms after uncomplicated mild head injury. J Head Trauma Rehab 8, 48-59.

Bazarian, J.J., McClung, J., Shah, M.N., Cheng, Y.T., Flesher, W., Kraus, J., 2005. Mild traumatic brain injury in the United States, 1998-2000. Brain Injury 19, 85-91.

Bazarian, J.J., Zhong, J., Blyth, B., Zhu, T., Kavcic, V., Peterson, D., 2007. Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: A pilot study. J Neurotrauma 24, 1447-1459.

Chu, Z., Wilde, E.A., Hunter, J.V., McCauley, S.R., Bigler, E.D., Troyanskaya, M., Yallampalli, R., Chia, J.M., and Levin, H.S., 2010. Voxel-Based Analysis of Diffusion Tensor Imaging in Mild Traumatic Brain Injury in Adolescents. Am J Neuroradiol 31, 340-346.

Cox, R.W., 1996. AFNI: Software for analysis and visualization of functional magnetic resonance Neuroimages. Comput Biomed Res 29, 162-173.

Cox, R.W., Jesmanowicz, A., 1999. Real-time 3D image registration for functional MRI. Magn Reson Med 42, 1014-1018.

Evans, A., Collins, D., Mills, S., Brown, E., Kelly, R., Peters, T., 1993. 3D statistical neuroanatomical models from 305 MRI volumes. In: Nuclear Science Symposium and Medical Imaging Conference. 1993 IEEE Conference Record 1813-1817.

Gennarelli, T.A., 1986. Mechanisms and pathophysiology of cerebral concussion. J Head Trauma Rehab 1, 23-29.

Henry, L.C., Tremblay, J., Tremblay, S., Lee, A., Brun, C., Lepore, N., Ellemberg, D., Lassonde, M., 2011. Acute and Chronic Changes in Diffusivity Measures after Sports Concussion. J Neurotrauma 28, 2049-2059.

Horsfield, M.A., 1999. Mapping eddy current induced field for the correction of diffusion weighted echo planar images. Magn Reson Imaging 17, 1335-1345.

Hulkower, M.B., Poliak, D.B., Rosenbaum, S.B., Zimmermann, M.E., Lipton, M.L., 2013. A Decade of DTI in Traumatic Brain Injury: 10 Years and 100 Articles Later. Am J Neuroradiol 34:2064-2074.

Jantzen, K.J., Anderson, B., Steinberg, F.L., Kelso, J.A.S., 2004. A prospective MR imaging study of mild traumatic brain injury in college football players. Am J Neuroradiol 25, 738-745.

Mayer, A.R., Ling, J., Mannell, M.V., Gasparovic, C., Phillips, J.P., Doezema, D., Reichard, R., Yeo, R.A., 2010. A prospective diffusion tensor imaging study in mild traumatic brain injury. Neurology 74, 643-650.

Nichols, T.E., Holmes, A.P., 2001. Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 15, 1-25.

Pearce, J.M.S., 2008. Observations on concussion. Eur Neurol 59, 113-119.

Povlishock, J.T., Becker, D.P., Cheng, C.L., Vaughan, G.W., 1983. Axonal change in minor head injury. J Neuropathol Exp Neurol 42, 225-242.

Ropper, A.H., Gorson, K.C., 2007. Concussion. N Engl J Med 356, 166-172.

Smith, D.H., Meaney, D.F., 2000. Axonal damage in traumatic brain injury. Neuroscientist 6, 483-495.

Smith, S.M., 2002. Fast robust automated brain extraction. Hum Brain Mapp 17, 143-155.

Smith, S.M., Jenkinson, M., Woolrich, M.W., Beckmann, C.F., Behrens, T.E.J., Johansen-Berg, H., Bannister, P.R., De Luca, M., Drobnjak, I., Flitney, D.E., Niazy, R., Saunders, J., Vickers, J.,
Zhang, Y., De Stefano, N., Brady, J.M., Matthews, P.M., 2004. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23(S1), 208-219.

Smith, S.M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T.E., Mackay, C.E.,
Watkins, K.E., Ciccarelli, O., Cader, M.Z., Mathews, P.M., Behrens, T.E.J., 2008. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31, 1487-1505.

Woolrich, M.W., Jbabdi, S., Patenaude, B., Chappell, M., Makni, S., Behrens, T., Beckmann, C., Jenkinson, M., Smith, S.M., 2009. Bayesian analysis of neuroimaging data in FSL. Neuroimage 45(S1), 73-186.

Xiong, Y., Mahmood, A., Chopp, M., 2013. Animal models of traumatic brain injury. Nat Rev Neurosci 14, 128-142.

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.